Influence of age on the relation between body position and noninvasively acquired intracranial pulse waves.

The capacitive measurement of the head's dielectric properties has been recently proposed as a noninvasive method for deriving surrogates of craniospinal compliance (CC), a parameter used in the evaluation of space-occupying neurological disorders. With the higher prevalence of such disorders in the older compared to the younger population, data on the head's dielectric properties of older healthy individuals would be of particularly high value before assessing pathologic changes. However, so far only measurements on young volunteers (< 30 years) were reported. In the present study, we have investigated the capacitively obtained electric signal known as W in older healthy individuals. Thirteen healthy subjects aged > 60 years were included in the study. W was acquired in the resting state (supine horizontal position), and during head-up and head-down tilting. AMP, the peak-to-valley amplitude of W related to cardiac action, was extracted from W. AMP was higher in this older cohort compared to the previously investigated younger one (0°: 5965 ± 1677 arbitrary units (au)). During head-up tilting, AMP decreased (+ 60°: 4446 ± 1620 au, P < 0.001), whereas it increased during head-down tilting (- 30°: 7600 ± 2123 au, P < 0.001), as also observed in the younger cohort. Our observation that AMP, a metric potentially reflective of CC, is higher in the older compared to the younger cohort aligns with the expected decrease of CC with age. Furthermore, the robustness of AMP is reinforced by the consistent relative changes observed during tilt testing in both cohorts.

Queckenstedt's test repurposed for the quantitative assessment of the cerebrospinal fluid pulsatility curve.

PURPOSE: Before the era of spinal imaging, presence of a spinal canal block was tested through gross changes in cerebrospinal fluid pressure (CSFP) provoked by manual compression of the jugular veins (referred to as Queckenstedt's test; QT). Beyond these provoked gross changes, cardiac-driven CSFP peak-to-valley amplitudes (CSFPp) can be recorded during CSFP registration. This is the first study to assess whether the QT can be repurposed to derive descriptors of the CSF pulsatility curve, focusing on feasibility and repeatability. METHOD: Lumbar puncture was performed in lateral recumbent position in fourteen elderly patients (59.7±9.3 years, 6F) (NCT02170155) without stenosis of the spinal canal. CSFP was recorded during resting state and QT. A surrogate for the relative pulse pressure coefficient was computed from repeated QTs (i.e., RPPC-Q). RESULTS: Resting state mean CSFP was 12.3 mmHg (IQR 3.2) and CSFPp was 1.0 mmHg (0.5). Mean CSFP rise during QT was 12.5 mmHg (7.3). CSFPp showed an average 3-fold increase at peak QT compared to the resting state. Median RPPC-Q was 0.18 (0.04). There was no systematic error in the computed metrics between the first and second QT. CONCLUSION: This technical note describes a method to reliably derive, beyond gross CSFP increments, metrics related to cardiac-driven amplitudes during QT (i.e., RPPC-Q). A study comparing these metrics as obtained by established procedures (i.e., infusion testing) and by QT is warranted.

The effect of body position change on noninvasively acquired intracranial pulse waves.

Objective. Craniospinal compliance (CC) is an important metric for the characterization of space-occupying neurological pathologies. CC is obtained using invasive procedures that carry risks for the patients. Therefore, noninvasive methods for acquiring surrogates of CC have been proposed, most recently based on changes in the head's dielectric properties during the cardiac cycle. Here, we have tested whether changes in body position, which are known to influence CC, are reflected in a capacitively acquired signal (hereinafter referred to as W) originating from dynamic changes of the head's dielectric properties.Approach. eighteen young healthy volunteers were included in the study. After 10 min in supine position, subjects were tilted head-up (HUT), back to 0° (horizontal, control), and then head-down (HDT). Metrics related to cardiovascular action were extracted from W, including AMP, the peak-to-valley amplitude of the cardiac modulation of W. Computational electromagnetic simulations were performed to probe the association between intracranial volume change and W.Main results. AMP decreased during HUT (0°: 2869 ± 597 arbitrary units (au); +75°: 2307 ± 490 au,P= 0.002) and increased during HDT (-30°: 4403 ± 1428 au,P< 0.0001). The same behavior was predicted by the electromagnetic model.Significance. tilting affects the distribution of CC between cranial and spinal compartments. Cardiovascular action induces compliance-dependent oscillatory changes in the intracranial fluid composition, which causes corresponding variations in the head's dielectric properties. These manifest as increasing AMP with decreasing intracranial compliance, which suggests that W may contain information related to CC, and that it might be possible to derive CC surrogates therefrom.

Noninvasive Monitoring of Intracranial Pulse Waves.

OBJECTIVE: The clinical management of several neurological disorders benefits from the assessment of intracranial pressure and craniospinal compliance. However, the associated procedures are invasive in nature. Here, we aimed to assess whether naturally occurring periodic changes in the dielectric properties of the head could serve as the basis for deriving surrogates of craniospinal compliance noninvasively. METHODS: We designed a device and electrodes for noninvasive measurement of periodic changes of the dielectric properties of the human head. We characterized the properties of the device-electrode-head system by measurements on healthy volunteers, by computational modeling, and by electromechanical modeling. We then performed hyperventilation testing to assess whether the measured signal is of intracranial origin. RESULTS: Signals obtained with the device on volunteers showed characteristic cardiac and respiratory modulations. Signal oscillations can be attributed primarily to changes in resistive properties of the head during cardiac and respiratory cycles. Reduction of end-tidal CO2, through hyperventilation, resulted in a decrease in the signal amplitude associated with cardiovascular action. CONCLUSION: Given the higher CO2 reactivity of intracranial vessels compared to extracranial ones, the results of hyperventilation testing suggest that the acquired signal is, in part, of intracranial origin. SIGNIFICANCE: If confirmed in larger cohorts, our observations suggest that noninvasive capacitive acquisition of changes in the dielectric properties of the head could be used to derive surrogates of craniospinal compliance.

Theory for a non-invasive diagnostic biomarker for craniospinal diseases.

Monitoring intracranial pressure (ICP) and craniospinal compliance (CC) is frequently required in the treatment of patients suffering from craniospinal diseases. However, current approaches are invasive and cannot provide continuous monitoring of CC. Dynamic exchange of blood and cerebrospinal fluid (CSF) between cranial and spinal compartments due to cardiac action transiently modulates the geometry and dielectric properties of the brain. The resulting impedance changes can be measured and might be usable as a non-invasive CC surrogate. A numerically robust and computationally efficient approach based on the reciprocity theorem was developed to compute dynamic impedance changes resulting from small geometry and material property changes. The approach was successfully verified against semi-analytical benchmarks, before being combined with experimental brain pulsation data to study the information content of the impedance variation. The results indicate that the measurable signal is dominated by the pulsatile displacement of the cortical brain surface, with minor contributions from the ventricular surfaces and from changes in brain perfusion. Different electrode setups result in complementary information. The information content from the investigated three electrode pairs was employed to successfully infer subject-specific brain pulsation and motion features. This suggests that non-invasive CC surrogates based on impedance monitoring could be established.

RAQ: A Noise-Resistant Calibration-Independent Compliance Surrogate.

The intracranial pressure (ICP)-volume relationship contains important information for diagnosing hydrocephalus and other space-occupying pathologies. We aimed to design a new parameter which quantifies the relationship and can be calculated from overnight recordings.The new parameter, the respiratory amplitude quotient (RAQ), characterizes the modulation of the pulse amplitude by the respiratory wave in the ICP time course. RAQ is defined as the ratio of the amplitude of the respiratory wave in the ICP signal to the amplitude of the respiration-induced wave in the course of the heartbeat-dependent pulse amplitude.We tested RAQ on synthetically generated ICP waveforms and found a mean difference of <0.5% between the calculated values of RAQ and the theoretically determined values. We further extracted RAQ from datasets obtained by overnight recording in hydrocephalus patients with a stenosis of the aqueduct and a comparison group finding a significant difference between the RAQ values of either group.

Why Hydrocephalus Patients Suffer When the Weather Changes: A New Hypothesis.

Hydrocephalus patients complain about symptoms related to weather changes, especially changes in atmospheric pressure (pat). We aimed to determine which physical, physiological, and pathophysiological effects can explain this phenomenon. We hypothesized that intracranial pressure (ICP) is influenced by changes of intracranial blood volume caused by autoregulatory changes in arterial diameter as a reaction to changing levels of arterial CO2 partial pressure (paCO2) caused by changes in atmospheric pressure (pat). To test this hypothesis, we investigated the influence of pat on paCO2, and then assessed the influence of paCO2 on ICP by extrapolating data found in the literature. Using conservative assumptions, we found that a change of pat of about 50 hPa will result in a change in ICP of above 1.65 mmHg, which could explain the symptoms patients reported.

RAQ: a novel surrogate for the craniospinal pressure-volume relationship.

OBJECTIVE: The intracranial pressure-volume relation contains information relevant for diagnostics of hydrocephalus and other space-occupying pathologies. We aimed to design a noise-resilient surrogate for this relationship that can be calculated from intracranial pressure (ICP) signals. APPROACH: The new surrogate, termed respiratory amplitude quotient (RAQ), characterizes the modulation of the cardiac pulse wave amplitude by the respiratory wave in the ICP time course. RAQ is defined as the ratio of the amplitude of the respiratory wave in the ICP signal to the amplitude of the respiration-induced variation in the course of the cardiac pulse wave amplitude. We validated the calculation of RAQ on synthetically generated ICP waveforms. We further extracted RAQ retrospectively from overnight ICP recordings in a cohort of hydrocephalus patients with aqueductal stenosis, age 55.8 ± 18.0 years, and a comparison group with hydrocephalus diagnosed by morphology in MRI, but not responsive to either external lumbar drainage or ventriculo-peritoneal shunting, age 72.5 ± 6.1 years. RAQ was determined for the full recordings, and separately for periods containing B-waves. MAIN RESULTS: We found a mean difference of less than 2% between the calculated values of RAQ and the theoretically determined equivalent descriptors of the synthetic ICP waveforms. In the overnight recordings, we found significantly different RAQ values during B-waves in the aqueductal stenosis (0.86 ± 0.11) and non-responsive hydrocephalus patient groups (1.07 ± 0.20), p = 0.027. In contrast, there was no significant difference in other tested parameters, namely pressure-volume index, elastance coefficient, and resistance to outflow. Neither did we find significant difference when considering RAQ over the full recordings. SIGNIFICANCE: Our results indicate that RAQ may function as a potential surrogate for the intracranial pressure-volume relation.

Significant Association of Slow Vasogenic ICP Waves with Normal Pressure Hydrocephalus Diagnosis.

OBJECTIVE: We aimed to test whether there is an association of slow vasogenic wave (SVW) occurrence with positive response to external lumbar drainage (ELD) and ventriculoperitoneal shunting and to design a method for the recognition and quantification of SVWs in the intracranial pressure (ICP) signal. MATERIALS AND METHODS: We constructed SVW templates using normalized sine waves. We calculated the cross-correlation between the respective SVW template and the ICP signal. This was followed by shifting the templates forward and performing the cross-correlation analysis again until the end of the recording. Cross-correlation values above a threshold were considered to be indicative of SVWs. This threshold was previously determined and validated on a sample of ICP records of six patients. We calculated the root mean square of the recognized SVW periods as a measure of signal strength. Time-averaged signal strength was calculated over the full recording time (ICPSmean) and over the wave periods (ICPS). RESULTS: We determined ICPS and ICPSmean in recordings of 2 groups of patients presenting with Hakim's triad: 26 normal pressure hydrocephalus (NPH) patients and 20 non-NPH patients. We then tested whether there was an association between ICPS or ICPSmean and the respective diagnosis using a Mann-Whitney test. We found significant association between ICPS (p = 0.014) and ICPSmean (p = 0.022) and the diagnoses. CONCLUSIONS: The described method based on pattern recognition in the time domain is suitable for the detection and quantification of SVWs in ICP signals. We found a significant association between the occurrence of SVWs and independent NPH diagnosis.

Magnetic microparticles for endovascular aneurysm treatment: in vitro and in vivo experimental results.

OBJECTIVE: Endovascular treatment of intracranial aneurysms employing endosaccular coiling can be associated with aneurysm perforation, coil herniation or incomplete obliteration fueling the interest to investigate novel endovascular techniques. We aimed to test a novel embolization material in experimental aneurysms in vitro and in vivo whereby intra-arterially administered magnetic microparticles (MMPs) are navigated into the lumen of vascular aneurysms with assistance from an external magnetic field. METHODS: MMPs are core-shell particles suspended in saline that have a shell made of a polymeric material and a core made of magnetite (Fe3O4). They have a diameter of 1.4 µm. During MMP administration via a microcatheter, a magnetic field was applied externally to direct the particles with the use of a solid-state neodymium magnet. Experiments were performed in a perfused silicone vessel and aneurysm model to evaluate application techniques and fluid dynamics and in the elastase aneurysm model in rabbits to evaluate in vivo compatibility, including multiorgan histological examinations and long-term stability of aneurysm embolization. RESULTS: It was possible to steer and hold the MMPs within the aneurismal cavity where they occluded the lumen progressively. After removal of the external magnetic field, the results remained stable in vivo for the remainder of the observational period (30 minutes); after a 12-week observational period, recanalization of the aneurysm occurred. CONCLUSION: MMPs can be magnetically directed into aneurysms, allowing short-term obliteration. Although the method has yet to show reliable long-term stability, these experiments provide proof of concept, encouraging further investigation of intravascular magnetic compounds.

Mounting device for external cerebrospinal fluid drainage: the Freiburg Stativ.

BACKGROUND: External drainage of cerebrospinal fluid (CSF) is one of the most common neurosurgical procedures. It is important to maintain a stable drainage rate, but with the commonly available mountings for CSF drainage this can be difficult to achieve. The drainage rate is dependent on the height-difference between the CSF space and the drip chamber of the device. Most mountings for open CSF drainage cannot be satisfactorily fixed at the bed of the patient; especially if the head of the bed is moved, there is a risk of over- or underdrainage. MATERIALS AND METHODS: We have therefore constructed a mounting for open CSF drainage which allows appropriate adjustment of the rate of CSF outflow, even if the patient's head part of the bed is moved. FINDINGS: The device was easily mountable or exchangeable at any hospital bed and served equally well for ventricular or for lumbar drainage. CONCLUSION: We think that this device can help to reduce serious complication of over- or underdrainage in external CSF drainage.